An extensive history of fundamental research is the cornerstone of our activity at ISEM, yet our work is also focused on current tangible societal issues. Our research nurtures the biomedical sector through the exploration of evolutionary medicine concepts, the study of cancers as evolving biological entities, and the biodiversity-health relationship, particularly in tropical environments. We are developing new animal health-friendly approaches in aquaculture breeding conditions in an intensification and emerging disease setting. Our research on the impact of past climatic and anthropogenic disturbances (global warming, forest fires, domestication) enables us to assess expected biosphere responses to environmental changes under way. Finally, our invasion biology and plant and animal conservation biology research places us in a whistleblower position with an intermediary role regarding the biodiversity crisis.